The Radiation Recall Syndrome refers to an acute inflammatory reaction that occurs in a radiation field following administration of a precipitating drug ("recall-triggering medication"). The precise mechanism for the reaction is unknown.
Recall Syndromes may involve:
(1) skin
(2) vagina
(3) oral mucosa
(4) lung
(5) esophagus
Precipitating drugs: usually an antineoplastic drug:
(1) dactinomycin
(2) methotrexate
(3) doxorubicin
(4) paclitaxel
(5) etoposide
(6) gemcitabine
(7) bleomycin
(8) simvastatin
(9) docetaxol
(10) fluorouracil
(11) hydroxyurea
(12) tamoxifen
(13) vinblastine
(14) high dose interferon
Features of the syndrome:
(1) The patient usually did not have an acute radiation reaction involving the affected area during the period of radiation treatment.
(2) There is not a threshold radiation dose.
(3) The reaction may occur weeks to years after the radiation exposure.
(4) The syndrome tends to be more severe if the period between the radiation exposure and the reaction is short.
(5) The reaction may range from mild inflammation to extensive necrosis.
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