medical decision support medical decision support
Sign In

Radiation-Induced Malignant Glioma Following Gamma Knife Radiosurgery for an Intracranial Arteriovenous Malformation (AVM)

Description

The use of radiosurgery to control an intracranial arteriovenous malformation can rarely be followed by development of a malignant glioma. Starke et al estimated the risk based upon a series of patients. The authors are from the University of Virginia in Charlottesville.


Patient selection: gamma knife radiosurgery (GKRS) for an intracranial arteriovenous malformation (AVM)

 

The estimated chance of developing a radiation-induced tumor at >= 10 years after GKRS was 0.64%.

 

There is a long lag period for tumor development, with risk extending for decades after GKRS. This can be important for patients treated as children or young adults.

 

Tumors may present:

(1) due to an intracranial mass effect

(2) as a finding on follow-up CNS imaging studies

 

The tumors are typically found near the site of the AVM.

 

The tumor often is a high-grade glioma such as a glioblastoma.


To read more or access our algorithms and calculators, please log in or register.

Specialty