Radiation-induced effects:
(1) coronary arteriosclerosis
(2) microvascular dysfunction
(3) conduction disturbances (RBBB, AV block, etc)
(4) valvular disease with stenosis or insufficiency
(5) heart failure with systolic and/or diastolic dysfunction
(6) restrictive cardiomyopathy
(7) myocarditis
(8) pericardial disease (pericarditis, pericardial effusion, constrictive pericarditis)
(9) myocardial fibrosis
Risk factors for cardiotoxicity (Jaworski et al):
(1) total radiation dose > 30 Gy
(2) high dose fraction (> 2 Gy per day)
(3) volume of heart irradiated
(4) presence of tumor next to the heart
(5) younger age at exposure
(6) number of years since the exposure
(7) type of radiation source (cobalt)
(8) cardiotoxic chemotherapy
(9) risk factors for atherosclerosis (diabetes, smoking, etc)
(10) relative field weighting
