Chronic pruritus can significantly affect a patient’s quality of life (QOL)


Proposed mechanism: deposition of starch within cutaneous nerves


Conditions associated with chronic pruritus may include:

(1) cholestasis

(2) hydroxyethyl starch-associated pruritus


Factors associated with a worse quality of life:

(1) magnitude (extent, duration and severity)

(2) intractable (unresponsive to any therapy)

(3) interference with sleep

(4) anxiety and/or depression (mental distress)

(5) interference with daily activities

(6) concurrent pain


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