A patient with a primary immunodeficiency syndrome often has involvement of the upper and/or lower respiratory tract.
Patient selection: primary immunodeficiency
The most common presentation is recurrent, severe infection starting in early childhood. There may also be a family history of immunodeficiency.
Involvement of the upper respiratory tract may include:
(1) sinusitis
(2) otitis media
(3) laryngeal angioedema
Involvement of the lower respiratory tract may involve:
(1) pneumonia
(2) bronchitis
(3) bronchiectasis
(4) interstitial lung disease (? associated with autoimmune manifestations)
(5) organizing pneumonia
(7) hilar lymphadenopathy
(8) hyperreactive airway disease
(9) primary lymphoma
(10) metastatic carcinoma
(11) pulmonary dysgenesis or airway malformations (associated with velocardiofacial syndrome)
A patient may also develop respiratory complications associated with therapy.
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Specialty: Immunology/Rheumatology
