Metastatic carcinoma to the eye may cause changes resembling a hypopyon.

The metastatic focus is located in the uvea (iris, ciliary body).


Tumors that have metastasized to this region include:

(1) retinoblastoma

(2) lung cancer

(3) squamous cell carcinoma of the esophagus


The presentation is variable and may include:

(1) conjunctivitis

(2) material in the dependent anterior chamber

(3) elevated intra-ocular pressure

(4) ocular pain

(5) hyphema


The diagnosis can be challenging, especially if the patient is not known to have cancer.

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