The prophylactic therapy to reduce risk of stroke in patients with atrial fibrillation depends on the age of the patient and other risk factors.
(1) age of the patient
(2) concurrent conditions
(3) past medical history
General Treatment Guidelines (1996)
neither aspirin nor warfarin indicated
either aspirin or warfarin can be used
warfarin is the drug of choice; if warfarin cannot be given, aspirin can be used
General Treatment Guidelines (1999)
under 60 years of age with no risk factors
none, or aspirin
aspirin or warfarin (INR 1.6 to 3.0)
aspirin or warfarin
warfarin (INR 2.5 to 3.0, consider 1.6 to 2.5 if >= 75 years), or aspirin
previous TIA or CVA
warfarin (INR 2.5 to 4.0), or warfarin (INR 2.5) PLUS aspirin
• If a patient cannot tolerate aspirin, then an alternative antiplatelet agent might be tried, such as clopidogrel or dipyridamole.
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Specialty: Hematology Oncology, Neurology, Clinical Laboratory, Pharmacology, clinical