Prognostic Scoring System of Buskirk et al for a Patient with Requiring Salvage Radiotherapy for Isolated PSA Increase After a Radical Prostatectomy

Description

Buskirk et al developed a prognostic score for men who require salvage radiation therapy following an isolated increase in PSA after a radical prostatectomy. This can help identify a patient who may require more aggressive management or may be a candidate for a novel therapy. The authors are from the Mayo Clinic.

Patient selection: prostate cancer with pathologic tumor Stage T2 or T3 treated with radical prostatectomy

Parameters:

(1) pathologic tumor stage of radical prostatectomy specimen

(2) Gleason score

(3) serum PSA prior to salvage radiation therapy

Parameter	Finding	Points
pathologic tumor stage	T2	0
	T3a	0
	T3b	1
Gleason score	2 to 6	0
	7	1
	8, 9 or 10	2
PSA prior to radiation therapy	< 0.5 ng/mL	0
	0.5 to 1.0 ng/mL	1
	> 1.0 ng/mL	2

total score =

= SUM(points for all 3 parameters)

Interpretation:

• minimum score: 0

• maximum score: 5

• The higher the score the worse the prognosis.

Total Score	Probability Relapse Free at 5 Years
0 or 1	70%
2	52%
3	25%
4 or 5	6%

estimated from Figure 4, page 989

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Description

Specialty

ICD-10