Prognostic Scores of Vander Poorten et al for Patients with Parotid Carcinoma

Description

Vander Poorten et al developed 2 prognostic scores for patients with parotid carcinoma. The first used clinical information while the second included information from the pathologic examination of the tumor. The work was done at the Netherlands Cancer Institute in Amsterdam.

Prognostic Score from Clinical Findings (PS1)

Parameter	Finding	Points
age at diagnosis	age in years	age
pain on presentation	no pain	1
	pain or numbness	2
T status of clinical TNM	T1	0
	T2	1
	T3	2
	T4	3
N status of clinical TNM	N0	0
	N1	1
	N2a	2
	N2b	3
	N2c	4
	N3	5
skin invasion	no invasion	1
	present	2
facial nerve dysfunction	intact function	1
	paresis and/or paralysis	2

prognostic score 1 (PS1) =

= (0.024 * (age in years)) + (0.62 * (points for pain)) + (0.44 * (points for T status)) + (0.45 * (points for N status)) + (0.63 * (points for skin invasion)) + (0.91 * (points for facial nerve dysfunction))

Interpretation:

• minimum score: around 2.64

• maximum score: around 10

• 4 prognostic groups identified with different 5 year recurrence free survival.

PS1	Group	5 year recurrence free rates (95% CI)
< 3.85	1	92.4% (73.0-98.1%)
3.85 - 4.74	2	82.5% (62.8-92.4%)
4.75 - 5.80	3	48.1% (26.1 - 67.1%)
> 5.80	4	22.8% (8.5-41.2%)

Prognostic Score After Examination of Resected Specimen (PS2)

Parameter	Finding	Points
age at diagnosis	age in years	age
T status of clinical TNM	T1	0
	T2	1
	T3	2
	T4	3
N status of clinical TNM	N0	0
	N1	1
	N2a	2
	N2b	3
	N2c	4
	N3	5
skin invasion	no invasion	1
	present	2
facial nerve dysfunction	intact function	1
	paresis and/or paralysis	2
perineural growth in the resected specimen	no	1
	yes	2
positive surgical margins	no	1
	yes	2

prognostic score 2 (PS2) =

= (0.018 * (age in years)) + (0.39 * (points for T status)) + (0.34 * (points for N status)) + (0.70 * (points for skin invasion)) + (0.56 * (points for facial nerve dysfunction)) + (0.78 * (points for perineural growth)) + (0.65 * (points for positive margin))

Interpretation:

• minimum score: around 2.35

• maximum score: around 10

• 4 prognostic groups identified with different 5 year recurrence free survival.

PS2	Group	5 year recurrence free rates (95% CI)
< 3.99	1	95% (69.5-99.3%)
3.99 - 4.80	2	82.5% (59.8-93.1%)
4.81 - 5.67	3	55.9% (30.8 - 75.1%)
> 5.67	4	42% (21.9-60.9%)

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Prognostic Scores of Vander Poorten et al for Patients with Parotid Carcinoma

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