Patient selection: male with brain metastases present at the time of relapse
Parameters:
(1) number of brain metastases
(2) metastases to liver and/or bone
(3) serum AFP and HCG concentrations
|
Parameter
|
Finding
|
Points
|
|
number of brain metastases
|
1
|
0
|
|
|
2 or more
|
1
|
|
metastases to bone and/or liver
|
no (no metastases to either)
|
0
|
|
|
yes (metastases to one or both)
|
1
|
|
serum AFP and HCG
|
both low
|
0
|
|
|
one or both elevated
|
1
|
where:
• A low serum AFP was <= 100 ng/mL.
• The method for analysis and the reference range for AFP were not given but from Table 1 the reference range is inferred as being <= 10 ng/mL.
• A low serum HCG was <= 5,000 IU/L.
• The method for analysis and the reference range for HCG were not given but from Table 1 the reference range is inferred as being <= 10 IU/L.
total score =
= SUM(points for all 3 parameters)
Interpretation:
• minimum score: 0
• maximum score: 3
• The higher the score the worse the overall prognosis.
|
Score
|
Risk
|
5 Year Survival
|
|
0
|
low
|
51%
|
|
1
|
intermediae
|
29%
|
|
2 or 3
|
high
|
6%
|
where the survival curve for each group was flat from 4 to 10 years
