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Prognostic Score of Zhu et al for a Patient with Non-Small Cell Lung Carcinoma (NSCLC) Based on the Systemic Inflammatory Response (SIR)

Description

Zhu et al reported a prognostic score for patients with nonoperable non-small cell lung cancer (NSCLC). This is based on the systemic inflammatory response. The authors are from the Second Affiliated Hospital of Zhejiang University and the Chinese National Ministry of Education in Hangzhou, People's Republic of China.


 

Patient selection: inoperable non-small-cell lung cancer

 

Outcome: overall and progression-free survival

 

Parameters in the week prior to initial chemotherapy:

(1) serum C-reactive protein (CRP) in mg/L

(2) serum LDH in U/L

(3) serum CA125 in U/mL

 

Parameter

Finding

Points

serum CRP

<= 20 mg/L

0

 

> 20 mg/L

1

serum LDH

<= 240 U/L

0

 

> 240 U/L

1

serum CA125

<= 70 U/mL

0

 

> 70 U/mL

1

 

where:

• The analytical methods and reference ranges were not given. All were reported as "elevated".

 

total score =

= SUM(points for all 3 parameters)

 

Interpretation:

• minimum score: 0

• maximum score: 3

• The higher the score the worse the prognosis.

 

Score

Median Overall Survival

Median Progression Free Survival

0

28 months

10.7 months

1

13 months

6.1 months

2

11.6 months

3.6 months

3

8 months

1.8 months

 


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