Description

Yang et al reported a prognostic score for a patient with newly diagnosed multiple myeloma with 1q+. 1a+ is a common high-risk cytogenetic abnormality which impacts survival. The authors are from Jilin University, Peking Union Medical College, Shanxi Medical University, Mayo Clinic and affiliated hospitals.

 


Patient selection: newly diagnosed multiple myeloma, 1q+

 

Parameters:

(1) International Staging System (ISS) stage, from I to III

(2) hypercalcemia

(3) serum LDH

(4) t(14;16)

 

Parameters

Findings

Points

ISS

I or II

0

 

III

1

hypercalcemia

no

0

 

yes

2

serum LDH

low or normal

0

 

elevated

1

t(14;16)

absent

0

 

present

3

 

total score =

= SUM(points for all of the parameters)

 

Interpretation:

• minimum score: 0

• maximum score: 7

 

Total Score

Risk Group

Median Overall Survival

0

low

59.8 months

1 to 3

intermediate

34.8 months

4 to 7

high

18.9 months

 


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