Yang et al reported a prognostic score for a patient with severe fever with thrombocytopenia syndrome (SFTS). The authors are from Jinan Hospital of Infectious Diseases and Jinan Vocational College of Nursing.
Patient selection: severe fever with thrombocytopenia syndrome (SFTS)
Parameters:
(1) Glasgow coma scale (from 3 to 15)
(2) serum LDH, as multiple of upper limit of normal (ULN)
(3) plasma aPTT, as multiple of upper limit of normal (ULN)
(4) SpO2 in percent
conscious state score =
= 15 - (GCS)
ratio of LDH to ULN =
= (LDH) / (ULN)
ratio of aPTT to ULN =
= (aPTT) / (ULN)
Parameter
Finding
Points
conscious state scale
0
0
1 to 3
2
4 to 6
4
7 to 9
6
10 to 12
8
13 to 15
10
serum LDH to ULN ratio
< 1
0
1 to 2.99
2
3 to 5.99
4
6 to 8.99
6
9 to 11.99
8
>= 12
10
aPTT to ULN ratio
< 1
0
1 to 1.49
2
1.5 to 1.99
4
2 to 2.49
6
2.5 to 2.99
8
>= 3
10
SpO2
>= 95%
0
90-94%
2
85-89%
4
80-85%
6
75-80%
8
< 75%
10
where:
• The table shows overlap for a GCS of 12.
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 40
• Survivors had scores 11.69 +/- 6.65 (upper limit 18.34)
• Non-survivors had scores 18.13 +/- 6.39 (lower limit 11.74)
• A score > 15 indicates a high risk for mortality.
Performance:
• The area under the ROC curve is 0.78.
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