Prognostic Score of Wu et al for a Patient with Hepatitis B Virus (HBV)-Related Acute-on-Chronic Liver Failure (COSSH-ACLF Score)

Patient selection: HBV-related acute-on-chronic liver failure (serum total bilirubin >= 5 mg/dL; INR >= 1.5; ascites and/or hepatic encephalopathy)

Outcome: short-term mortality (28 day and 90 day)

Parameters:

(1) INR

(2) HBV-SOFA, from 4 to 12

(3) age in years

(4) serum total bilirubin in mg/dL

score =

= SUM(points for all 4 parameters)

Interpretation:

• minimum score: around 2.9

• maximum score: around 12.4

• The higher the score the greater the 28 and 90 day mortalities.

• A serum total bilirubin >= 12 mg/dL is associated with short-term mortality.

Performance:

• The area under the ROC curve for 28-day mortality was 0.81.