Prognostic Score of Trape et al for Advanced Non-Small Cell Lung Cancer (NSCLC)

Description

Trape et al reported a prognostic score for a patient with advanced non-small cell lung cancer (NSCLC). This can help to identify a patient who may benefit from more aggressive management or a novel therapy. The authors are from Xarxa Assistencial Universitaria de Manresa in Spain

Patient selection: advanced non-small cell lung cancer (NSCLC)

Outcome: overall survival

Parameters:

(1) ECOG performance status

(2) metastases

(3) serum CA 125 U/mL

(4) serum CYFRA 21-1 in ng/mL (cytokeratin 19 fragment)

(5) white blood cell count per µL

Parameter	Finding	Points
ECOG performance status	0 or 1	0
	2 to 4	1
metastases	absent	0
	present	1
serum CA125	<= 35 U/mL	0
	> 35 U/mL	1
serum CYFRA 21-1	<= 3.3 ng/mL	0
	> 3.3 ng/mL	1
WBC count	<= 10,000 per µL	0
	> 10,000 per µL	1

score for number of adverse prognostic factors =

= SUM(points for all of the parameters)

Interpretation:

• minimum score: 0

• maximum score: 5

• The higher the score the worse the prognosis.

Score	Hazard Ratio
0 or 1	1
2 or 3	2.7
4 or 5	8.8

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Prognostic Score of Trape et al for Advanced Non-Small Cell Lung Cancer (NSCLC)

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