Pisani et al reported a score for evaluating a neonate who has had a seizure. This can help to identify a neonate who is at risk for neurologic sequelae. The authors are from the University of Parma in Italy and Aston University in Birmingham.
Patient selection: neonate with seizure
Outcome: neurologic sequelae
Parameters:
(1) birthweight in grams
(2) Apgar score at 1 minute
(3) neurologic exam
(4) anticonvulsant therapy efficacy
(5) ultrasound brain scan
(6) status epilepticus
(7) background EEG activity
Parameters |
Findings |
Points |
birthweight |
< 1,000 grams |
3 |
|
1,000 to 1,499 grams |
2 |
|
1,500 to 2,499 grams |
1 |
|
>= 2,500 grams |
0 |
Apgar score at 1 minute |
0 to 3 |
2 |
|
4 to 7 |
1 |
|
8 to 10 |
0 |
neurologic exam |
normal |
0 |
|
mildly abnormal |
0 |
|
moderately abnormal |
1 |
|
severely abnormal |
2 |
anticonvulsant therapy |
immediate response |
0 |
|
partial response |
1 |
|
no response |
2 |
ultrasound brain scan |
normal |
0 |
|
IVH 1 or IVH 2; transient periventricular echodensities; borderline ventricular dilation |
1 |
|
IVH 3 or IVH 4; intra-parenchymal hemorrhage; periventricular leukomalacia; brain malformation |
2 |
status epilepticus |
absent |
0 |
|
present |
1 |
background EEG activity |
normal; excessive sharp activity; absent or decreased frequency of normal patterns; excessively long low-voltage periods or overall slightly decreased voltage |
0 |
|
asymmetries in voltage or frequencies; asynchrony for age, isoelectric or low-voltage invariant activity; burst suppression pattern; permanent discontinuous activity |
1 |
score 1 =
= SUM(points of first 6 items)
score 2 =
= SUM(points for all 7 items)
Interpretation:
• minimum score 1 or score 2: 0
• maximum score 1: 12
• maximum score 2: 13
• A value >= 4 for score 1 was associated with neurologic sequelae.
Performance:
• The sensitivity was 86% and specificity 81%.
Specialty: Neurology, Pedatrics