Description

Pisani et al reported a score for evaluating a neonate who has had a seizure. This can help to identify a neonate who is at risk for neurologic sequelae. The authors are from the University of Parma in Italy and Aston University in Birmingham.


Patient selection: neonate with seizure

 

Outcome: neurologic sequelae

 

Parameters:

(1) birthweight in grams

(2) Apgar score at 1 minute

(3) neurologic exam

(4) anticonvulsant therapy efficacy

(5) ultrasound brain scan

(6) status epilepticus

(7) background EEG activity

 

Parameters

Findings

Points

birthweight

< 1,000 grams

3

 

1,000 to 1,499 grams

2

 

1,500 to 2,499 grams

1

 

>= 2,500 grams

0

Apgar score at 1 minute

0 to 3

2

 

4 to 7

1

 

8 to 10

0

neurologic exam

normal

0

 

mildly abnormal

0

 

moderately abnormal

1

 

severely abnormal

2

anticonvulsant therapy

immediate response

0

 

partial response

1

 

no response

2

ultrasound brain scan

normal

0

 

IVH 1 or IVH 2; transient periventricular echodensities; borderline ventricular dilation

1

 

IVH 3 or IVH 4; intra-parenchymal hemorrhage; periventricular leukomalacia; brain malformation

2

status epilepticus

absent

0

 

present

1

background EEG activity

normal; excessive sharp activity; absent or decreased frequency of normal patterns; excessively long low-voltage periods or overall slightly decreased voltage

0

 

asymmetries in voltage or frequencies; asynchrony for age, isoelectric or low-voltage invariant activity; burst suppression pattern; permanent discontinuous activity

1

 

score 1 =

= SUM(points of first 6 items)

 

score 2 =

= SUM(points for all 7 items)

 

Interpretation:

• minimum score 1 or score 2: 0

• maximum score 1: 12

• maximum score 2: 13

• A value >= 4 for score 1 was associated with neurologic sequelae.

 

Performance:

• The sensitivity was 86% and specificity 81%.


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