Pignatti et al identified prognostic factors for patients with low grade cerebral gliomas. This can help identify patients who may benefit from more aggressive management. The authors are from the European Organization for Research and Treatment of Cancer Brain Tumor Cooperative Group and Radiotherapy Cooperative Group.
Parameters:
(1) age of the patient in years
(2) largest diameter of the tumor
(3) location relative to the midline
(4) histologic type
(5) neurologic deficit
|
Parameter |
Finding |
Points |
|
age of the patient in years |
< 40 years of age |
0 |
|
|
>= 40 years of age |
1 |
|
largest diameter of the tumor |
< 6 cm |
0 |
|
|
>= 6 cm |
1 |
|
location relative to midline |
does not cross the midline |
0 |
|
|
crosses the midline |
1 |
|
histologic type |
oligodendroglioma or mixed oligoastrocytoma |
0 |
|
|
astrocytoma |
1 |
|
neurologic deficit |
none |
0 |
|
|
present |
1 |
total score =
= SUM(points for all 5 parameters)
Interpretation:
• minimum score: 0
• maximum score: 5
• The higher the score the greater the risk.
|
Total Score |
Risk Group |
Median Survival |
|
0 to 2 |
low risk |
7.7 years |
|
3 to 5 |
high risk |
3.2 - 3.7 years |
Lang and Gilbert found the following median survival for each score:
|
Total Score |
Median Survival |
|
0 |
9.2 years |
|
1 |
8.6 years |
|
2 |
5.8 years |
|
3 |
3.5 years |
|
4 |
1.9 years |
|
5 |
0.7 years |
Specialty: Hematology Oncology, Surgery, general, Neurology
