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Prognostic Score of Nowakowski et al for a Patient with T-Cell Large Granular Lymphocytic Leukemia (LGLL)

Description

Nowakowski et al developed a simple prognostic model for patients with T-Cell Large Granular Lymphocytic Leukemia (LGLL). This can help to identify a patient who may benefit from more aggressive management. The authors are from the Mayo Clinic in Rochester.


 

Patient selection: T-cell large granular lymphocytic leukemia

 

Parameters:

(1) hemoglobin

(2) absolute neutrophil count

(3) absolute lymphocyte count

 

Parameter

Finding

Points

hemoglobin

>= 12 g/dL

0

 

< 12 g/dL (anemia)

1

absolute neutrophil count

>= 100 per µL

0

 

< 100 per µL (severe neutropenia)

1

absolute lymphocyte count

>= 1,000 per µL

0

 

< 1,000 per µL (lymphopenia)

1

 

where:

• There is no distinction for gender in the grading of anemia.

• It is not stated whether the lymphocyte count includes the LGL or not.

 

total score =

= SUM(points for all 3 parameters)

 

Interpretation:

• minimum score: 0

• maximum score: 3

• The higher the score the worse the overall survival.

 

Score

Median Survival

5 Year Survival

0

105 months

62%

1

55 months

50%

2 or 3

5months

12%

 


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