Prognostic Score of Nordlinger et al for Surgical Resection of Colorectal Carcinoma Metastases to the Liver

Description

Nordlinger et al reported a prognostic score for a patient undergoing resection of liver metastases from a colorectal carcinoma. This can help to identify a patient who may benefit from more aggressive therapy or a novel intervention. The authors are from Hopital Saint Antoine in Paris.

Patient selection: surgical resection of hepatic metastases from a colorectal carcinoma

Parameters:

(1) age in years

(2) serosal invasion of primary tumor (T4)

(3) lymph node metastases from primary tumor (N1 or N2)

(4) liver metastases less than 2 years after diagnosis of colon primary (disease-free interval)

(5) diameter of metastasis in cm

(6) number of liver metastases

(7) shortest distance between tumor and resection margin in cm

Parameters	Findings	Points
age in year	< 60 years	0
	>= 60 years	1
serosal invasion	absent	0
	present	1
lymph node metastases	no	0
	yes	1
time to liver metastases	< 2 years	1
	>= 2 years	0
diameter of liver metastasis	< 5 cm	0
	>= 5 cm	1
number of liver metastases	1 to 3	0
	>= 4	1
shortest distance to resection margin	<= 1 cm	1
	> 1 cm	0

total score =

= SUM(points for all 7 parameters)

Interpretation:

• minimum score: 0

• maximum score: 7

• The higher the score the worse the prognosis.

Total Score	Risk Group	2-Year Survival
0 to 2	low	79%
3 or 4	intermediate	60%
5 to 7	high	43%

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Prognostic Score of Nordlinger et al for Surgical Resection of Colorectal Carcinoma Metastases to the Liver

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