Prognostic Score of Nguyen and Graviss for a Patient with Tuberculosis and Diabetes

Description

Nguyen and Graviss reported a score for predicting mortality for a patient with both tuberculosis and diabetes. This can help to identify a patient who may benefit from more aggressive management. The authors are from Houston Methodist Research Institute.

Patient selection: tuberculosis and diabetes, receiving antituberculous therapy, United States resident

Parameters:

(1) age in years

(2) location of birth

(3) homelessness

(4) intravenous drug use

(5) chronic kidney failure

(6) TB meningitis

(7) miliary tuberculosis

(8) AFB sputum smear positive

(9) HIV status

Parameter	Finding	Points
age in years	< 65 years	0
	>= 65 years	16
location of birth	USA	5
	other	0
homeless	no	0
	yes	11
IV drug use	no	0
	yes	20
chronic kidney failure	no	0
	yes	20
TB meningitis	no	0
	yes	20
miliary TB	no	0
	yes	13
AFB sputum smear	negative	0
	positive	6
HIV status	negative	0
	positive	24

total score =

= SUM(points for all of the parameters)

Interpretation:

• minimum score: 0

• maximum score: 135

Score	Mortality Risk
<= 11	low
12 to 21	medium
>= 22	high

value of X =

= (0.1 * (score)) - 4

probability of mortality =

= 1 / (1 + EXP((-1) * X))

Performance:

• The area under the ROC curve is 0.82.

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Prognostic Score of Nguyen and Graviss for a Patient with Tuberculosis and Diabetes

Description

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