Montalban et al reported a simple score for evaluating a patient with splenic marginal zone lymphoma. This can help to identify a patient who may benefit from more aggressive management. The authors are from multiple institutions in Spain and Italy.
Patient selection: splenic marginal zone lymphoma
Outcome: 5-year lymphoma-specific survival (LSS)
Parameters:
(1) hemoglobin in g/dL
(2) platelet count per µL
(3) serum LDH activity in U/L
(4) extrahilar lymphadenopathy
Parameter
Finding
Points
hemoglobin
>= 9.5 g/dL
0
< 9.5 g/dL
1
platelet count
>= 80,000 per µL
0
< 80,000 per µL
1
serum LDH
normal
0
high (> ULN)
1
extrahilar lymphadenopathy
absent
0
present
1
total score =
= SUM(point for all 4 parameters)
Interpretation:
• minimum score: 0
• maximum score: 4
• The higher the score the worse the prognosis.
Score
Risk Group
5 Year Lymphoma-Specific Survival (LSS)
0
A
95%
1 or 2
B
87%
3 or 4
C
68%
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