Liu et al reported a prognostic score for a patient with unclassified myelodysplastic syndrome or myelodysplastic syndrome/myeloproliferative neoplasm. This can help to identify a patient who may benefit from more aggressive management.
Parameters:
(1) absolute neutrophil count per microliter
(2) peripheral blood blasts
(3) hemoglobin in g/dL
(4) serum LDH in U/L
(5) age in years
Parameter
Finding
Points
absolute neutrophil count
< 8,500 per µL
0
>= 8.500 per µL
2
blasts in peripheral blood
absent
0
present
2
hemoglobin
> 11.5 g/dL
0
<= 11.5 g/dL
2
serum LDH
< 550 U/L
0
>= 550 U/L
2
age
< 65 years
0
>= 65 years
3
total score =
= SUM(points for all 5 parameters)
Interpretation:
• minimum score: 0
• maximum score: 11
• The higher the score the worse the prognosis.
Score
Risk Group
Median Overall Survival
0 to 3
favorable
67.4 months
4 to 6
intermediate
28.9 months
7 to 11
poor
13.1 months
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