Le Scodan et al identified prognostic factors for a woman with breast cancer that is metastatic to the brain. The authors are from Centre Rene Huguenin in Saint Cloud, France.
Patient selection: woman with breast cancer metastatic to brain
Parameters:
(1) RTOG recursive partitioning analysis (RPA) class of Gaspar et al (or Karnofsky Performance Status, KPS)
(2) absolute lymphocyte count
(3) hormone receptor status
Parameter |
Finding |
Points |
RTOG RPA Class |
I or II (KPS >= 70) |
0 |
|
III (KPS < 70) |
|
absolute lymphocyte count |
> 700 per µL |
0 |
|
<= 700 per µL |
1 |
hormone receptor |
positive |
0 |
|
negative |
1 |
where:
• Hormone receptor (HR) status was not defined. It is at least estrogen receptor negative.
number of risk factors =
= SUM(points for all 3 parameters)
Interpretation:
• minimum number of risk factors: 0
• maximum number of risk factors: 3
• The prognosis worsens as the number of risk factors increase.
Number of Risk Factors |
Overall Survival 1 Year |
0 |
61% |
1 |
21% |
2 or 3 |
16% |
Specialty: Hematology Oncology, Surgery, general