Le Scodan et al identified prognostic factors for a woman with breast cancer that is metastatic to the brain. The authors are from Centre Rene Huguenin in Saint Cloud, France.
Patient selection: woman with breast cancer metastatic to brain
Parameters:
(1) RTOG recursive partitioning analysis (RPA) class of Gaspar et al (or Karnofsky Performance Status, KPS)
(2) absolute lymphocyte count
(3) hormone receptor status
Parameter
Finding
Points
RTOG RPA Class
I or II (KPS >= 70)
0
III (KPS < 70)
absolute lymphocyte count
> 700 per µL
0
<= 700 per µL
1
hormone receptor
positive
0
negative
1
where:
• Hormone receptor (HR) status was not defined. It is at least estrogen receptor negative.
number of risk factors =
= SUM(points for all 3 parameters)
Interpretation:
• minimum number of risk factors: 0
• maximum number of risk factors: 3
• The prognosis worsens as the number of risk factors increase.
Number of Risk Factors
Overall Survival 1 Year
0
61%
1
21%
2 or 3
16%
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