Kong et al developed a prognostic score for patients with diffuse large B-cell lymphoma (DLBCL). This can help to identify patients who may benefit from more aggressive management and those who do not. The authors are from Shandong University.
Patient selection: diffuse large B-cell lymphoma
Parameters:
(1) age of the patient in years
(2) stage
(3) gene expression profiling (GEP) subtype
(4) interim PET/CT after the second chemotherapy cycle
Parameter
Finding
Points
age of the patient
<= 60 years
0
> 60 years
1
stage
I or II
0
III or IV
1
GEP subtype
GCB (germinal center)
0
ABC (activated B-cell)
1
interim PET/CT
negative
0
positive
1
total score =
= SUM(points for all 4 parameters)
Interpretation:
• minimum score: 0
• maximum score: 4
• The higher the score the worse the prognosis.
Total Score
Risk Group
3-Year Overall Survival
0 or 1
low risk
100%
2
low-intermediate
91%
3
high-intermediate
56%
4
high risk
0%
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