Prognostic Score of Garcia-Manero et al for a Patient with Lower Risk Myelodysplastic Syndrome (LR-PSS)

Description

Garcia-Manero et al developed a prognostic score for patients with lower risk myelodysplasia. This can help to identify patients with a worse prognosis who may benefit from more aggressive management. The authors are from the University of Texas MD Anderson Cancer Center in Houston.

Patient selection: myelodysplastic syndrome with IPSS low or intermediate-1

Parameters:

(1) cytogenetics

(2) age in years

(3) hemoglobin in g/dL

(4) platelet count in 10^9/L

(5) percent bone marrow blasts

Parameter	Finding	Points
cytogenetics	favorable (diploid or 5q)	0
	unfavorable	1
age in years	< 60 years of age	0
	>= 60 years of age	2
hemoglobin	>= 10 g.dL	0
	< 10 g/dL	1
platelet count	> 200 * 10^9/L	0
	50 to 200 * 10^9/L	1
	< 50 * 10^9/L	2
percent bone marrow blasts	< 4%	0
	>= 4%	1

total score =

= SUM(points for all 5 parameters)

Interpretation:

• minimum score: 0

• maximum score: 7

• The higher the score the worse the prognosis.

• A person in category 3 may benefit from early intervention.

Score	Category	Risk	Median Survival
0 to 2	1	good	80 months
3 or 4	2	fair	27 months
5 to 7	3	poor	14 months

where:

• More strata could be used. For example, the 4-year survival for a score of 0 or 1 is about 80% while it is 50% for a score of 2 (all in category 1).

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Description

Specialty

ICD-10