Ferreri et al developed a prognostic score for patients with primary CNS lymphoma. This can help identify those patients who may benefit from more aggressive or who may be a candidate for investigational therapy. The authors are from the International Extranodal Lymphoma Study Group.
Parameters:
(1) age
(2) ECOG performance status
(3) serum LDH
(4) CSF protein level
(5) region of brain involvement
|
Parameter |
Finding |
Points |
|
age in years |
age <= 60 years |
0 |
|
|
age > 60 years |
1 |
|
ECOG performance status |
0 or 1 |
0 |
|
|
2, 3 or 4 |
1 |
|
serum LDH |
<= upper limit of reference range |
0 |
|
|
> upper limit of reference range |
1 |
|
CSF protein |
<= 45 mg/dL if <= 60 years of age |
0 |
|
|
> 45 mg/dL if <= 60 years of age |
1 |
|
|
<= 60 mg/dl if > 60 years of age |
0 |
|
|
> 60 mg/dL if > 60 years of age |
1 |
|
regions of brain involvement |
does not involve deep region(s) of the CNS |
0 |
|
|
involves the deep region(s) of the brain (periventricular region, basal ganglia, brainstem, and/or cerebellum) |
1 |
total score =
= SUM(points for all 5 parameters)
Interpretation:
• minimum score: 0
• maximum score: 5
• The higher the risk, the worse the prognosis.
|
Total Score |
Risk Group |
24 month survival |
|
0 or 1 |
low risk |
80 +/- 8% |
|
2 or 3 |
intermediate risk |
48 +/- 7% |
|
4 or 5 |
high risk |
15 +/- 7% |
Specialty: Hematology Oncology
