Fanale et al reported a simple prognostic score for a patient with nodular lymphocyte predominant Hodgkin lymphoma (NLPHL). The author is from MD Anderson Cancer Center.
Patient selection: nodular lymphocyte predominant Hodgkin Lymphoma (NLPHL)
Parameters:
(1) histologic subtype
(2) serum albumin in g/dL
(3) gender
Histologic Subtype
Features
A
classic B-cell rich nodular
B
serpiginous/interconnected nodular
C
nodular with prominent extranodular lymphocytic and histiocytic cells
D
T-cell rich nodular
E
diffuse with T-cell rich background
F
diffuse B-cell rich
where:
• A T-cell rich background is an independent predictor of relapse.
Parameter
Finding
Points
histologic subtype
typical (A or B)
0
variant (C, D, E or F)
1
serum albumin
>= 4 g/dL
< 4 g/dL
gender
female
male
2
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 4
Total Score
Risk Group
5-Year Overall Survival
0 or 1
low
98.7%
intermediate
96.2%
3 or 4
high
88.3%
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Specialty: Hematology Oncology
