Prognostic Score of Curran et al for Pleural Mesothelioma Based on the European Organization for Research and Treatment of Cancer (EORTC) Clinical Trials (EORTC Prognostic Score, EPS)

Parameters:

(1) white blood cell (WBC) count

(2) ECOG performance status

(3) certainty of histologic diagnosis

(4) histologic subtype

(5) patient gender

where:

• Patients with a definite histologic diagnosis of mesothelioma had a better survival than those with less certainty.

• Patients with poor performance status (ECOG 3 or 4) were not included but would be expected to have a poor outcome.

number of factors present =

= SUM(points for all 5 parameters)

prognostic score =

= (0.55 * (points for WBC count)) + (0.60 * (points for performance status)) + (0.52 * (points for histologic certainty)) + (0.67 * (points for histologic subtype)) + (0.60 * (points for gender))

Interpretation:

• minimum score: 0

• maximum score: 2.94

• minimum number of risk factors: 0

• maximum number of risk factors: 5