Condoluci et al reported a prognostic score for patients with early stage chronic lymphocytic leukemia (CLL). This can help to identify a patient who is likely to progress and require therapy. The authors are from multiple institutions in Europe, Israel and the United States.
Patient selection: early stage CLL (Binet A)
Parameters:
(1) absolute lymphocyte count
(2) palpable lymph nodes
(3) palpable spleen
(4) IGHV gene
(5) trisomy 12
Parameters
Findings
Points
absolute lymphocyte count
<= 15,000 per µL
0
> 15,000 per µL
1
palpable lymph nodes
absent
0
present
1
palpable spleen
absent
0
present
1
IGHV gene
mutated
0
unmutated
1
trisomy 12
absent
0
present
1
total score =
= SUM(points for all 5 parameters)
Interpretation:
• minimum score: 0
• maximum score: 5
• The higher the score the shorter the time to progression and need for first treatment.
Total Score
Risk Group
4-Year Need for Therapy
0
low
5%
1
intermediate
12%
2 to 5
high
53%
Performance:
• The area under the ROC curve is 0.77.
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