Soumerai et al reported a prognostic risk score for patients with relapsed or refractory chronic lymphocytic leukemia (CLL). This can help to identify a patient at high risk of death who may benefit from aggressive or novel therapies. The authors are from multiple institutions in the United States, England and Australia.
Patient selection: relapsed or refractory CLL
Parameters:
(1) serum beta-2 microglobulin concentration
(2) serum LDH concentration
(3) hemoglobin and sex
(4) time from last therapy in months
Parameter
Finding
Points
serum beta-2 microglobulin
< 5 mg/dL
0
>= 5 mg/dL
1
serum LDH
<= ULN
0
> ULN
1
hemoglobin and sex
female and >= 110 g/L
0
female and < 110 g/L
1
male and >= 120 g/L
0
male and < 120 g/L
1
time from last therapy
>= 24 months
0
< 24 months
1
total score =
= SUM(points for all 4 parameters)
Interpretation:
• minimum score: 0
• maximum score: 4
• The higher the score the greater the risk.
Score
Risk Group
0 or 1
low
2 or 3
intermediate
4
high
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