Cai et al reported a nomogram for predicting survival in a patient with a diffuse large B-cell lymphoma (DLBCL). The authors are from Sun Yat-sen University, Capital Medical University and affiliated hospitals in China.
Patient selection: diffuse large B-cell lymphoma
Parameters:
(1) age in years
(2) serum LDH in U/L
(3) ECOG performance status
(4) Ann Arbor stage
(5) number of extranodal sites
(6) BCL2
(7) CD5
(8) B symptoms
(9) absolute lymphocyte count per microliter
(10) absolute monocyte count per microliter
Parameter
Finding
Points
age in years
<= 60 years
0
> 60 years
86
serum LDH
<= 245 U/L
0
> 245 U/L
48.3
ECOG PS
0 or 1
0
2 to 4
100
Ann Arbor stage
I or II
0
III or IV
53.2
extranodal sites
0 or 1
0
>= 2
55.8
BCL2
negative
0
positive
51
CD5
negative
0
positive
70.9
B symptoms
absent
0
present
30.5
absolute lymphocyte count
> 1,000 per µL
0
<= 1,000 per µL
36.2
absolute monocyte count
< 630 per µL
0
>= 630 per µL
64
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 596
value of X =
= (-0.00001563 * ((score)^2)) - (0.005423 * (score)) + 3.253
probability of 5-year overall survival =
= 1 / (1 + EXP((-1) * X))
Performance:
• The area under the ROC curve is 0.83 in both the training and validation cohorts.
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