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Prognostic Models of Zeng et al for a Patient with a Nasopharyngeal Carcinoma: Model for Local Recurrence-Free Survival (LRFS)

Description

Zeng et al developed several prognostic models for a patient with nasopharyngeal carcinoma. One model predicted local recurrence-free survival (LRFS). The authors are from Collaborative Innovation Center of Cancer Medicine, Sun Yat-Sen University Cancer Center, Jiangxi Cancer Hospital Nanchang and Shantou University Medical College.


 

Patient selection: nasopharyngeal carcinoma

 

Outcome: 5-year local recurrence-free survival (LRFS)

 

Parameters:

(1) primary gross tumor volume in mL over range from 0 to 200

 

points for gross tumor volume =

= (volume in mL) / 2

 

Interpretation:

• minimum score: 0

• maximum score: 100

• The higher the score the greater the risk for local recurrences.

 

Score

Risk Group

5-Year DMFS

< 49

low

94%

>= 49

high

78%

 

 

Score

5-Year LRFS

< 20

> 85%

20 to 90

(-0.000033 * ((score)^2)) - (0.001384 * (score)) + 0.8905

> 90

< 50%

 

Performance status:

• The c-index was 0.66.

 


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