Zhu et al reported a prognostic model for a patient with mantle cell lymphoma. This can help to identify a patient who may benefit from more aggressive management. The authors are from Soochow University in Changzhou, China.
Patient selection: mantle cell lymphoma
Presentation of model: nomogram
Parameters:
(1) Ki-67 in percent
(2) WBC count in 10^9/L
(3) age in years
(4) ECOG performance status
(5) ratio of serum LDH to upper limit of normal
Parameter |
Finding |
Points |
Ki-67 |
<30% |
0 |
|
>= 30% |
98 |
WBC |
< 6.7 * 10^9/L |
0 |
|
6.7 to 9.99 |
9.6 |
|
10 to 14.99 |
19.2 |
|
>= 15 |
29.6 |
age |
< 50 |
0 |
|
50 to 59 |
13.8 |
|
60 to 69 |
27.5 |
|
>= 70 |
41.5 |
ECOG |
0 or 1 |
0 |
|
2 to 4 |
100 |
LDH to ULN ratio |
< 0.67 |
0 |
|
0.67 to 0.99 |
29 |
|
1.00 to 1.49 |
58.8 |
|
>= 1.5 |
88 |
total score =
= SUM(points for all 5 parameters)
Interpretation:
• minimum score: 0
• The higher the score the worse the overall survival.
Score |
1-Year Overall Survival |
< 127.7 |
> 90% |
127.7 to 234.2 |
(-0.0015016 * ((score)^2)) + (0.2623 * (score)) + 80.948 |
234.2 to 335 |
177.75 - (0.5048 * (score)) |
> 335 |
< 10% |
Score |
3-Year Overall Survival |
< 54.2 |
> 90% |
54.2 to 158 |
(-0.001599 * ((score)^2)) + (0.05337 * (score)) + 91.659 |
158 to 259.7 |
139.48 - (0.50198 * (score)) |
> 259.7 |
< 10% |
Specialty: Hematology Oncology