Prognostic Model of Xie et al for a Patient with Acute-on-Chronic Liver Failure (ACLF) Receiving Plasma Exchange Liver Support (APM Score)

Patient selection: ACLF on a plasma exchange life support system (artificial liver support system, ALLS)

APM = ALSS prognosis model

Criteria for ACLF:

(1) serum total bilirubin >= 5 mg/dL

(2) INR >= 1.5

(3) ascites and/or hepatic encephalopathy withn 4 weeks

(4) chronic liver disease

Parameters:

(1) age in years

(2) serum total bilirubin i mg/dL

(3) INR

(4) serum AFP in µg/L

APM score =

= SUM(points for all of the parameters)

Interpretation:

• The higher the score the worse the prognosis.

• The equation is reportedly a logistic regression model. However, further analysis is not specified.

Performance:

• The area under the ROC curve is 0.79.