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Prognostic Model of Shulman and Benaim for Event-Free Survival (EFS) in a Man with Androgen-Independent Prostate Carcinoma

Description

Shulman and Benaim developed a prognostic model for event-free survival (EFS) in men with androgen-independent prostate cancer. This can help identify patients who may benefit from more aggressive management. The authors are from the University of Texas Southwestern Medical Center and the Veterans Affairs Hospital in Dallas.


 

Patient selection: prostate cancer with disease progression during androgen deprivation therapy

 

Model: derived by recursive partitioning analysis

 

Parameters:

(1) metastatic prostate cancer at time of diagnosing androgen-independent disease progression

(2) time to PSA recurrence

(3) PSA doubling time

PSA Doubling Time

Metastatic Disease

Time to PSA Recurrence

Risk Group

> 10 months

NA

NA

low

<= 10 months

absent

NA

intermediate

<= 10 months

present

> 13 months

intermediate

<= 10 months

present

<= 13 months

high

 

 

Risk Group

Mean EFS in months

Mean Number of Bone Events

low

96 months

0.3

intermediate

34 (28 - 43) months

0.7

high

6 months

1.4

 


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