Prognostic Model of Scarisbrick et al for Patients with Advanced Stage Mycosis Fungoides or Sezary Syndrome

Description

Scarisbrick et al developed a prognostic model for patients with mycosis fungoides or Sezary syndrome. This can help to identify a patient who may benefit from more aggressive or a novel therapy. The authors are from the Cutaneous Lymphoma International Consortium.

Patient selection: Mycosis fungoides or Sezary syndrome, stages IIB to IV (advanced stage)

Parameters at time of initial diagnosis:

(1) stage

(2) age in years

(3) large cell transformation (LCT)

(4) serum LDH concentration

Parameter	Finding	Points
stage	stage IV	1
	not stage IV	0
age in years	<= 60 years	0
	> 60 years	1
large cell transformation	no	0
	yes	1
serum LDH concentration	normal	0
	elevated	1

total score =

= SUM(points for all 4 parameters)

Interpretation:

• minimum score: 0

• maximum score: 4

• The higher the score the worse the 5-year overall survival.

Score	Risk	5-Year OS
0 or 1	low	68%
2	intermediate	44%
3 or 4	high	28%

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Prognostic Model of Scarisbrick et al for Patients with Advanced Stage Mycosis Fungoides or Sezary Syndrome

Description

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