Perry et al developed a simple score for determining the prognosis for a patient with a diffuse large B-cell lymphoma (DLBCL). The authors are from multiple institutions in North America and Europe.
Patient selection: diffuse large B-cell lymphoma
Parameters:
(1) classification of Choi et al (see 28.07.88)
(2) stromal signature using antibody against SPARC (secreted protein, acidic, rich in cysteine), in percent of tumor stromal cells positive
(3) microvessel density (MVD) quartile
Parameter
Finding
Points
classification (Choi)
GCB (germinal center B-cell)
0
non-GCB
1
SPARC positive
< 5%
1
>= 5%
0
microvessel density
fourth quartile
1
other quartile
0
total score =
= SUM(points for all 3 parameters)
Interpretation:
• minimum score: 0
• maximum score: 3
• The higher the score the worse the prognosis.
Total Score
Prognosis
7-Year Overall Survival
0 or 1
good
70%
2 or 3
poor
18%
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