medical decision support medical decision support
Sign In

Prognostic Model of Ma et al for an Adult Patient with Acute Myeloid Leukemia (AML)

Description

Ma et al reported a model for predicting survival for an adult with acute myeloid leukemia (AML). The authors are from Shanghai Jiao Tong University in Shanghai, China.


Patient selection: adult with AML

 

Parameters:

(1) age in years

(2) hematopoietic cell transplant comorbidity index (HCT-CI)

(3) WBC count in 10^9/L

(4) hemoglobin in g/L

(5) biallellic CEBPA

(6) DNMT3A

(7) FLT3-ITD/NPM1 status

(8) European Leukaemic Net (ELN) cytogenetic risk status

 

Parameter

Finding

Points

age in years

< 65 years

0

 

>= 65 years

2.4

HCT-CI

< 1

0

 

>= 1

3.8

WBC count

< 50 * 10^9/L

0

 

>= 50 * 10^9/L

2.7

hemoglobin

>= 100 g/L

0

 

60 to 99.9 g/L

3.4

 

< 60 g/L

5.0

biallelic CEBPA

mutated

0

 

wild type

5.4

 

monoallelic

5.4

DNMT3

wild type

0

 

mutated

4.4

FLT3-ITD/NPM1

ITD(-), NPM1(+)

0

 

ITD(-), NPM1(-)

4.4

 

ITD(+), NPM1(+)

5.3

 

ITD(+), NPM1(-)

10

ELN cytogenetic risk

favorable

0

 

intermediate

3.0

 

adverse

8.0

 

total score =

= SUM(points for all of the parameters)

 

Interpretation:

• minimum score: 0

• maximum score: 41.7

 

Total Score

Probability of 3-Year Survival

< 6.8

> 90%

6.8 to 23.9

(0.00009546 * ((score)^3)) - (0.005918 * ((score)^2)) + (0.06025 * (score)) + 0.7294

> 23.9

< 10%

 


To read more or access our algorithms and calculators, please log in or register.

Specialty