Kanemasa et al reported a prognostic model for patients with diffuse large B-cell lymphoma (DLBCL). This can help to predict the risk of an isolated CNS relapse after initial management. The authors are from Metropolitan Cancer and Infectious Disease Center Komagome Hospital in Tokyo.
Patient selection: diffuse large B-cell lymphoma involving the central nervous system
Parameters:
(1) number of extranodal sites
(2) serum albumin in g/dL
(3) retroperitoneal lymph node involvement
(4) Ann Arbor stage
Parameter
Finding
Points
number of extranodal sites
0 or 1
0
2 or more
1
serum albumiin
>= 3.5
0
< 3.5
1
retroperitoneal lymph node
no
0
yes
1
Ann Arbor stage
I or II
0
III or IV
1
total score =
= SUM(number of parameters present)
Interpretation:
• minimum number of risk factors: 0
• maximum number of risk factors: 4
Total Score
Risk Group
5-Year Risk Isolated CNS Relapse
0 to 2
low
2.5%
3 or 4
high
11.7%
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