Prognostic Model of Hahn et al for Event-Free Survival After Bone Marrow Transplantation (BMT) for a Patient with Relapsed and Refractory Hodgkin's Disease (RPCI Prognostic Model)

Description

Hahn et al reported a prognostic model for a patient with Hodgkin's disease who is undergoing bone marrow transplantation (BMT). This can identify a patient who may benefit from more aggressive management. The authors are from Roswell Park Cancer Institute in Buffalo.

Patient selection: relapsed and refractory Hodgkin's disease, treated with autologous or allogeneic BMT

Outcome: event-free survival (EFS)

Parameters:

(1) number of prior regimens

(2) chemo-sensitivity of the Hodgkin's diseaes

(3) Karnofsky Performance Status at time of BMT (KPS, from 10 to 100)

Parameter	Finding	Points
number of prior regiments	< 3	0
	>= 3	1
chemosensitivity	sensitive or not evaluated	0
	resistant	1
Karnofsky Performance	>= 90	0
	< 90	1

total score =

= SUM(points for all 3 parameters)

Interpretation:

• minimum score: 0

• maximum score 3

• The higher the score the worse the event-free survival.

Score	Risk Group	4-Year EFS (all patients)
0 or 1	low risk	55%
2 or 3	high risk	0%

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Prognostic Model of Hahn et al for Event-Free Survival After Bone Marrow Transplantation (BMT) for a Patient with Relapsed and Refractory Hodgkin's Disease (RPCI Prognostic Model)

Description

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