Federico et al developed a prognostic model specifically for follicular non-Hodgkins lymphoma starting from the International Prognostic Index. Patients with a poor prognosis may benefit from more aggressive therapy, while patients with a good prognosis may be adequately managed with less toxic regimens.
Parameters:
(1) age
(2) sex
(3) number of extranodal sites
(4) serum LDH level
(5) B symptoms
(6) erythrocyte sedimentation rate
|
Parameter |
Finding |
Points |
|
age |
<= 60 |
0 |
|
|
> 60 |
1 |
|
sex |
female |
0 |
|
|
male |
1 |
|
extranodal sites |
0 or 1 |
0 |
|
|
>= 2 |
1 |
|
serum LDH |
normal |
0 |
|
|
elevated |
1 |
|
B symptoms |
absent |
0 |
|
|
present |
1 |
|
erythrocyte sedimentation rate (ESR) |
< 30 mm in first hour |
0 |
|
|
>= 30 mm in first hour |
1 |
where:
• B symptoms are one or more of the following: (a) recurrent fever > 38°C, (b) night sweats, or (c) unexplained weight loss of > 10% normal body weight
number of prognostic factors =
= SUM(points for all 6 parameters)
Interpretation:
• minimum score: 0
• maximum score: 6
|
Number of Risk Factors |
5 Year Survival Rate |
Risk Group |
|
0 |
97% |
low |
|
1 |
87% |
low |
|
2 |
75% |
intermediate |
|
3 |
49% |
high |
|
4 |
14% |
high |
|
5 or 6 |
0% |
high |
from Table 4, page 786
|
Risk Group |
10 Year Survival Rate |
|
low |
65% |
|
intermediate |
54% |
|
high |
11% |
Specialty: Hematology Oncology
