Delgado et al developed a simple prognostic model for patients with chronic lymphocytic leukemia (CLL) using 2 biomarkers which influence prognosis. This can help to identify patients who may benefit from more aggressive management. The authors are from the University of Barcelona, University Hospital Brno, Masaryk University and Azienda Ospedaliera di Cosenza.
Patient selection: CLL
Outcome: overall survival
Parameters:
(1) IGHV mutational status
(2) FISH cytogenetics for del(17p) and del(11q)
IGHV Status
FISH del(17p) or del(11q)
Risk Group
mutated
neither
low
mutated
either or both
intermediate
unmuated
neither
intermediate
unmuated
either or both
hgih
Risk Group
10-Year Overall Survival
low
82%
intermediate
52%
high
27%
Age >= 65 years was associated with a worse overall survival compared to < 65 years.
Risk Group
10 Year OS
Age < 65 Years
10 Year OS
Age >= 65 Years
low
92%
69%
intermediate
62%
39%
high
36%
7%
estimated from Figure 1 page 377
Performance for marker-only model:
• The area under the ROC curve was 0.68.
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