Jurczyszyn et al reported prognostic indicators for a patient with primary plasma cell leukemia. This can help to identify a patient who may benefit from more aggressive management. The authors are from multiple institutions in Europe, Israel and the United States.
Patient selection: primary plasma cell leukemia
Parameters:
(1) age in years
(2) platelet count in 10^9/L
(3) absolute plasma cell count in the peripheral blood in 10^9/L
Parameter
Finding
Points
age in years
< 60 years
0
>= 60 years
1
platelet count
> 100 * 10^9/L
0
<= 100 * 10^9/L
1
absolute plasma cell count
< 20 * 10^9/L
0
>= 20 * 10^9/L
1
number of indicators =
= SUM(points for all 3 parameters)
Interpretation:
• minimum number of indicators: 0
• maximum number of indicators: 3
• The overall survival declines as the number of prognostic indicators increases.
Number of Indicators
Median Overall Survival
0
46 months
1
27 months
2 or 3
12 months
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