Smith et al developed a prognostic score for children with Hodgkin's disease. This can help identify patients who may require more aggressive management or who may benefit from novel therapies. The authors are from the Stanford University, St.Jude Children's Hospital, Dana-Farber Cancer Institute and Massachusetts General Hospital.
Patient selection: age range from 2 to 20 years with a median age of 14.
Parameters (based on pretreatment findings):
(1) gender
(2) stage of Hodgkin's disease
(3) mediastinal disease
(4) WBC count
(5) hemoglobin
Parameter
Finding
Points
gender
female
0
male
1
stage of Hodgkin's disease
I, IIA or IIIA
0
IIB, IIIB or IV
1
mediastinal disease
non-bulky
0
bulky
1
WBC count
<= 13,500 per µL
0
> 13,500 per µL
1
hemoglobin
>= 11.0 g/dL
0
< 11.0 g/dL
1
total score =
= SUM(points for all 5 parameters)
Interpretation:
• minimum score: 0
• maximum score: 5
Total Score
5 year Disease Free Survival
5 Year Overall Survival
0 or 1
94%
99%
2
85%
96%
3
71%
92%
4 or 5
49%
72%
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