Kang et al reported a prognostic index for patients with diffuse large B-cell lymphoma. This can help to identify a patient who may benefit from more aggressive management. The authors are from the University of Ulsan in Seoul.
Patient selection: diffuse large B-cell lymphoma
Outcome: overall survival
Parameters:
(1) age in years
(2) serum LDH activity in U/L relative to the upper limit of the normal reference range (ULN)
(3) ECOG performance status
(4) Ann Arbor stage
(5) serum beta-2-microglobulin in mg/L
Parameter
Finding
Points
age in years
<= 60 years
0
> 60 years
1
serum LDH
<= ULN
0
> ULN
1
ECOG performance status
0 or 1
0
>= 2
1
Ann Arbor stage
I or II
0
III or IV
1
beta-2-microglobulin
<= 2.5 mg/L
0
> 2.5 mg/L
1
total score =
= SUM(points for all 5 parameters)
Interpretation:
• minimum score: 0
• maximum score: 5
• The higher the score the worse the outcome.
Total Score
Risk Group
5-Year Overall Survival
0
low
95%
1
low-intermediate
86%
2 or 3
high-intermediate
69%
4 or 5
high
48%
Performance:
• The area under the ROC curve is 0.79.
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