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Prognostic Importance of Absolute Eosinophilia or Basophilia Associated with Myelodysplasia

Description

Wimazal et al evaluated the prognostic significance of eosinophilia and/or basophilia for a patient with myelodysplasia. The authors are from the Medical University of Vienna, Heinrich-Heine Univeristy and Ludwig-Boltzmann Institute for Leukemia Research and Hematology in Vienna.


 

Patient selection: myelodyplastic syndrome

 

Eosinophilia is an absolute eosinophil count > 350 per µL.

Basophilia is an absolute basophile count > 250 per µL.

 

Hazard Ratio for Increased Mortality

IPSS

Eosinophilia/Basophilia

LDH >= 300 IU/L

low

14.4

89.2

intermediate 1

3.5

2.1

intermediate 2

4.1

1.1

high

0.35

2.1

 

where:

• Eosinophilia/basophilia is superior to LDH for intermediate-2 patients.

 


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Specialty

ICD-10