Herndon et al used classification and regression tree (CART) analysis to stratify patients with malignant mesothelioma into prognostic groups. This can help identify patients who may be candidates for more aggressive treatment. The authors are from the Cancer and Leukemia Group B (CALGB) representing multiple university hospitals in the United States.
Patient selection: ECOG performance score 0 to 2
Parameters:
(1) ECOG performance score (PS)
(2) age in years
(3) hemoglobin in grams per dL
(4) white blood cell (WBC) count in thousands
(5) chest pain (CP)
(6) unintended weight loss (WL)
|
PS |
Age |
Hgb |
WBC |
CP |
WL |
Node |
|
0 |
< 49 |
NA |
NA |
NA |
NA |
A |
|
0 |
>= 49 |
>= 14.6 |
NA |
NA |
NA |
B |
|
0 |
>= 49 |
< 14.6 |
NA |
NA |
NA |
C |
|
1-2 |
NA |
NA |
< 8.7 |
N |
NA |
D |
|
1-2 |
NA |
NA |
8.7-15.59 |
N |
NA |
E |
|
1-2 |
NA |
>= 12.3 |
< 15.6 |
Y |
N |
F |
|
1-2 |
NA |
< 12.3 |
< 15.6 |
Y |
N |
G |
|
1-2 |
NA |
>= 11.2 |
9.8-15.59 |
Y |
Y |
H |
|
1-2 |
NA |
< 11.2 |
9.8-15.59 |
Y |
Y |
I |
|
1-2 |
NA |
NA |
< 9.8 |
Y |
Y |
J |
|
1-2 |
NA |
NA |
>= 15.6 |
NA |
NA |
K |
from Figure 1, page 727 (Herndon et al)
|
Nodes |
Group |
Median Survival in Months |
Probability 2 Year Survival |
|
A, B |
1 |
13.9 |
38% |
|
D |
2 |
9.5 |
21% |
|
C, F, H |
3 |
9.2 |
10% |
|
E |
4 |
6.5 |
6% |
|
G, I, J |
5 |
4.4 |
0% |
|
K |
6 |
1.4 |
0% |
from Table 4, page 728 (Herndon et al)
Specialty: Hematology Oncology, Surgery, general, Pulmonology
