Cady et al identified genetic markers associated with the prognosis for a patient with a primary central nervous system (CNS) lymphoma (PCNSL). These can help to identify a patient who may benefit from more aggressive management. The authors are from CellNetix Pathology in Olympia, Washington, and the Mayo Clinic in Rochester.


Patient selection: primary CNS lymphoma


Prognostic markers:

(1) del(6)(q22) = deletions from chromosome 6q, which is associated with a loss of tumor suppression

(2) rearrangements in BCL6


The presence of one or both of these markers was associated with a worse prognosis compared to a patient with neither. The presence of both was not additive to the presence of only 1 factor.


2 Year Overall Survival

3 Year Overall Survival

0 factors



1 or 2 factors




Other factors:

(1) age < 60 years was associated with a more favorable overall survival


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