Prognostic Factors of Yendamuri et al Determining Survival for a Patient with Esophageal Cancer

 

Patient selection: either squamous cell carcinoma or adenocarcinoma without preoperative chemoradiation and without distant metastases (not M1).

 

Parameters:

(1) T status of the tumor

(2) N status of the tumor

(3) length of the tumor in cm

(4) status of final surgical margin

Parameter	Finding	Hazard Ratio
T status	T1	1
	T2	1.9
	T3 or T4	3.5
N status	N0	1
	N1	1.9
length of the tumor	<= 3 cm	1
	> 3 cm	2.1
status of final surgical margin	negative for tumor	1
	positive for tumor	2.7

 

cumulative hazard ratio =

= PRODUCT(all 4 parameters)

 

Interpretation:

• minimum cumulative hazard ratio: 1

• maximum cumulative hazard ratio: 37.7

• The higher the cumulative hazard ratio the greater the mortality rate.

• The length of the tumor affected survival. A small tumor (<= 1 cm) had a 5 year survival rate of 83% while a tumor > 3 cm had a survival less than 20%.