Weisenburger et al reported prognostic factors for a patient with a peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS). These can help to identify a patient who may benefit from more aggressive management. The authors are participants in the International Peripheral T-Cell Lymphoma Project.


Patient selection: peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS)


Key factors associated with a poor prognosis on stepwise multivariate analysis:

(1) International Prognostic Index (IPI, 28.07.04) >= 3 (3, 4 or 5)

(2) > 70% transformed tumor cells



• The best survival was seen with an IPI of 0 or 1.

• An IPI of 2 had survival between the good and the bad.

• The IPI is based on age, serum LDH, performance status, Ann Arbor stage and extranodal involvement.


Additional adverse prognostic factors identified on univariate analysis:

(1) bulky disease (tumor mass > 10 cm in diameter)

(2) thrombocytopenia (platelet count < 150,000 per µL)

(3) B symptoms

(4) elevated serum C-reactive protein (CRP)

(5) circulating tumor cells (in the peripheral blood)


Favorable prognostic factors on univariate analysis:

(1) presence of hypergammaglobulinemia


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